Recent Advances in the Synthesis of Heterocycles via Gold-catalyzed Cascade Reactions: A Review

Author(s): Feng Gao, Yu Zhou, Hong Liu*.

Journal Name: Current Organic Chemistry

Volume 21 , Issue 15 , 2017

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Abstract:

Background: Heterocyclic scaffolds widely occur in natural products and pharmaceutical molecules and because of their broad biological activities, the synthesis of such frameworks with diverse approaches is one of the most attractive fields in modern organic chemistry. Recently, cascade reactions catalyzed by transition metals made astounding advances in the synthesis of heterocyclic compounds for their step economy. Among them, gold-catalyzed cascade reactions emerged as important tools to construct complicated heterocyclic architecture from simple precursors in the past decade.

Objective: This review presents an overview of recent advances in gold-catalyzed cascade reactions to generate diverse heterocyclic scaffolds and its applications in total synthesis of natural products.

Keywords: Gold, transition metals, cascade reactions, tandem reactions, domino reactions, heterocycles, natural products.

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Article Details

VOLUME: 21
ISSUE: 15
Year: 2017
Page: [1530 - 1566]
Pages: 37
DOI: 10.2174/1385272821666170102144500
Price: $58

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