Introduction: Diabetes Mellitus (DM) is a metabolic disorder characterized by chronic hyperglycaemia,
which is attributed to several life threatening complications including atherosclerosis,
nephropathy, and retinopathy. The current therapies available for the management of DM mainly include
oral antidiabetic drugs and insulin injections. However, continuous use of synthetic drugs provides
lower healing with many side effects. Therefore, there is an urge for safe and efficient antidiabetic
drugs for the management of DM. In the continuing search for effective antidiabetic drugs, marine algae
(seaweeds) remains as a promising source with potent bioactivity. It is anticipated that the isolation,
characterization, and pharmacological study of unexplored marine algae can be useful in the discovery
of novel antidiabetic compounds with high biomedical value. Among marine algae, brown and red algae
are reported to exhibit antidiabetic activity. Majority of the investigations on algal derived compounds
controls the blood glucose levels through the inhbition of carbohydrate hydroloyzing enzymes and protein
tyrosine phosphatase 1B enzymes, insulin sensitization, glucose uptake effect and other protective
effects against diabetic complications.
Conclusion: Based on the above perspective this review provides; profiles for various marine algae
posessing antidiabetic activity. This study also highlights the therapeutic potential of compounds isolated
from marine algae for the effective management of diabetes and its associated complications.