The Quest for Novel Biomarkers in Early Diagnosis of Diabetic Neuropathy

Author(s): Mihaela Adriana Ghita, Constantin Caruntu*, Daniela Lixandru, Adriana Pitea, Alexandra Batani, Daniel Boda.

Journal Name: Current Proteomics

Volume 14 , Issue 2 , 2017

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Abstract:

Diabetic neuropathy is the most common complication of diabetes mellitus and a major factor associated with foot ulcers and amputations in patients with diabetes. Diagnosing diabetic neuropathy in early stages may reduce the risk for comorbidities. However, it still represents a major challenge for the healthcare providers, despite the complexity of available techniques. Discovering new serum biomarkers, useful for early diagnosis of diabetic neuropathy and monitoring the disease progression is of growing interest for the scientific research. In this regard, the field of proteomics is extremely promising. Mass spectrometry technology and bioinformatic analysis of proteomic data accelerated the detection of biomarkers related to peripheral nervous system pathology. Herein, we analyze what role proteomics approaches play in the modern diagnostic strategy of diabetic neuropathy.

Keywords: Biomarker, diabetes, diabetic neuropathy, diagnosis, mass spectrometry, proteomics.

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Article Details

VOLUME: 14
ISSUE: 2
Year: 2017
Page: [86 - 99]
Pages: 14
DOI: 10.2174/1570164614666161228122259
Price: $58

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