Objective: We have synthesized new quinolidinyl-thiazolidinones via Knoevenagel condensation-
alkylation reaction, catalyzed by [Et3NH][HSO4]. The present approach offers several advantages
such as higher yields, eco-friendly reaction condition and economic availability of the catalyst.
Method: The newly synthesized compounds were evaluated for their in vitro antifungal activity against
six fungal strains. Some of the synthesized conjugates displayed good to moderate antifungal activity.
Conclusion: Again, the molecular docking study performed against the fungal sterol 14α-demethylase
(CYP51) showed an excellent binding affinity towards the enzyme which could rationalize the promising
antifungal activity portrayed by these derivatives and provides a platform for structure based drug design.
Keywords: Antifungal activity, ionic liquid, molecular docking, multicomponent reaction, 2, 4-thiazolidinones, solvent-free
Rights & PermissionsPrintExport