Drug Repurposing in Anticancer Reagent Development
Background: Cancer is a complex disease and a huge threat to human health. The
prognosis for some cancer types such as breast cancer has improved dramatically over the past 50
years due to rapid development of surgery, chemotherapy and radiotherapy technologies. However,
for many patients bearing unresectable cancers, the prognosis remained poor. For this reason, there is
always high demand for newer and better therapeutic reagents in cancer field. But the development
of anticancer drugs is risky, lengthy and costly. Not many new anticancer reagents come into market
Objective: This review focuses on the latest progress of chemotherapy drug repurposing in cancer
Conclusion: It is clear from the review of that drug repurposing is faster and cheaper than
conventional drug development process. The anticancer efficacy of numerous non-cancer drugs are
being tested now. However, not many of them have obtained enough evidence to go into clinical
trials for cancer treatment. How to filter the right candidate and narrow the gap between bench and
bed remains a hurdle for both conventional and repurposing drug development.
Keywords: Drug repurposing, cancer, mechanism, target, signaling pathway, cellular experiments.
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