The development of new screening models for cancer therapy is indispensable for the
improvement of cancer treatment, and for the creation of alternative possibilities in the field of
chemotherapy. Screening models are routinely used to reduce the cost and resources involved in
anticancer drug development. The value of any screening model will ultimately be ascertained by its
ability to reliably predict the clinical response. Traditional in vivo screening models have been
replaced with cell-based screening assays, and these cell-based models are under constant
development to better mimic in vivo conditions. In this review, the developmental phases of
anticancer screening models are discussed and exemplified, including the two-dimensional, threedimensional,
cancer stem cell, and non-mammalian screening models. In addition, the use of new
virtual screening tools as a model for anticancer drug development is highlighted.
Keywords: Anticancer, Drosophila, drug discovery, screening model, virtual screening, yeast, Zebrafish.
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