A defective immunorregulation has been demonstrated at different levels in autoimmune disease
and in multiple sclerosis (MS) in particular, which can be partly restored by therapies used for MS.
This fact highlights the relevance of promoting specific tolerance for central nervous system antigens for
the prevention of MS. In the present review, we summarize recent findings on the role of the diverse regulatory
immune cell subsets to convey an integrated view of MS pathogenesis in the framework of the
immune and psychoneuroendocrine metasystem. We also discuss the effects of MS therapies on these
regulatory cells’ subsets, and their implications in the cellular therapy of the disease.
Keywords: Regulatory T cells, tolerogenic dendritic cells, IL-10, multiple sclerosis, TGF-β.
Rights & PermissionsPrintExport