Thinking Outside the Brain: Immunorregulation in Multiple Sclerosis

Author(s): Lidia Fernandez-Paredes, Marta Tejera-Alhambra, Clara de Andres, Silvia Sanchez-Ramon.

Journal Name: Current Immunology Reviews

Volume 12 , Issue 2 , 2016

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Abstract:

A defective immunorregulation has been demonstrated at different levels in autoimmune disease and in multiple sclerosis (MS) in particular, which can be partly restored by therapies used for MS. This fact highlights the relevance of promoting specific tolerance for central nervous system antigens for the prevention of MS. In the present review, we summarize recent findings on the role of the diverse regulatory immune cell subsets to convey an integrated view of MS pathogenesis in the framework of the immune and psychoneuroendocrine metasystem. We also discuss the effects of MS therapies on these regulatory cells’ subsets, and their implications in the cellular therapy of the disease.

Keywords: Regulatory T cells, tolerogenic dendritic cells, IL-10, multiple sclerosis, TGF-β.

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Article Details

VOLUME: 12
ISSUE: 2
Year: 2016
Page: [98 - 111]
Pages: 14
DOI: 10.2174/1573395513666161223122517
Price: $58

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