CREB is an ubiquitous transcription factor regulating diverse
cellular responses. Its phosphorylation at S133 is an essential event for its
activation in both nervous and visual systems. The activated CREB is
implicated in the regulation of development, protection, learning, memory
and plasticity in the nerve system. Moreover, sumoylation, an important
post-translational modification of protein, plays a key role in sustaining
CREB activation in the rat hippocampus in order to enhance the long-term
memory and other aspects. In the visual system, although the CREB
activation by phosphorylation at S133 is similar to that as observed in the
nervous system, the role of CREB sumoylation remains to be explored. This
review will discuss the aspects of CREB functions and their regulation by phosphorylation
and sumoylation in both systems.
Keywords: CREB, eye, lens, phosphorylation, sumoylation, nervous system, visual system.
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