Abstract
CREB is an ubiquitous transcription factor regulating diverse cellular responses. Its phosphorylation at S133 is an essential event for its activation in both nervous and visual systems. The activated CREB is implicated in the regulation of development, protection, learning, memory and plasticity in the nerve system. Moreover, sumoylation, an important post-translational modification of protein, plays a key role in sustaining CREB activation in the rat hippocampus in order to enhance the long-term memory and other aspects. In the visual system, although the CREB activation by phosphorylation at S133 is similar to that as observed in the nervous system, the role of CREB sumoylation remains to be explored. This review will discuss the aspects of CREB functions and their regulation by phosphorylation and sumoylation in both systems.
Keywords: CREB, eye, lens, phosphorylation, sumoylation, nervous system, visual system.
Current Molecular Medicine
Title:Regulation of CREB Functions by Phosphorylation and Sumoylation in Nervous and Visual Systems
Volume: 16 Issue: 10
Author(s): L. Wang, X.-H. Hu, Z.-X. Huang, Q. Nie, Z.-G. Chen, J.-W. Xiang, R.-L. Qi, T.-H. Yang, Y. Xiao, W.-J. Qing, G. Gigantelli, Q. D. Nguyen and D. W.-C. Li
Affiliation:
Keywords: CREB, eye, lens, phosphorylation, sumoylation, nervous system, visual system.
Abstract: CREB is an ubiquitous transcription factor regulating diverse cellular responses. Its phosphorylation at S133 is an essential event for its activation in both nervous and visual systems. The activated CREB is implicated in the regulation of development, protection, learning, memory and plasticity in the nerve system. Moreover, sumoylation, an important post-translational modification of protein, plays a key role in sustaining CREB activation in the rat hippocampus in order to enhance the long-term memory and other aspects. In the visual system, although the CREB activation by phosphorylation at S133 is similar to that as observed in the nervous system, the role of CREB sumoylation remains to be explored. This review will discuss the aspects of CREB functions and their regulation by phosphorylation and sumoylation in both systems.
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Wang L., Hu X.-H., Huang Z.-X., Nie Q., Chen Z.-G., Xiang J.-W., Qi R.-L., Yang T.-H., Xiao Y., Qing W.-J., Gigantelli G., Nguyen D. Q. and Li W.-C. D., Regulation of CREB Functions by Phosphorylation and Sumoylation in Nervous and Visual Systems, Current Molecular Medicine 2016; 16 (10) . https://dx.doi.org/10.2174/1566524016666161223110106
DOI https://dx.doi.org/10.2174/1566524016666161223110106 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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