Effects of Crosstalks Between Sumoylation and Phosphorylation in Normal Cellular Physiology and Human Diseases

Author(s): Q. Nie, X.-D. Gong, M. Liu, D. W.-C. Li.

Journal Name:Current Molecular Medicine

Volume 16 , Issue 10 , 2016

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Abstract:

Post-translational modifications (PTMs) such as phosphorylation, acetylation, methylation, ubiquitylation, sumoylation are important mechanisms to regulate functions of different proteins. Among various PTMs, phosphorylation, discovered about 60 years ago, is probably the most common modification. In contrast, sumoylation, identified about two decades ago is emerging as a key regulatory mechanism modulating protein functions. Although studies on protein phosphorylation and sumoylation have been extensively reviewed, much less attention has been paid to their cross-talk and their co-regulation of the same protein target. Here we summarize various examples of the cross-talks between protein phosphorylation and sumoylation, and discuss their functions in regulating normal physiology and pathogenesis.

Keywords: PTM, phosphorylation, sumoylation, protein functions.

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Article Details

VOLUME: 16
ISSUE: 10
Year: 2016
Page: [906 - 913]
Pages: 8
DOI: 10.2174/1566524016666161223105555
Price: $58