Sumoylation Pathway as Potential Therapeutic Targets in Cancer
D. W.-C. Li.
Sumoylation is a covalent protein posttranslational modification
that conjugates the small ubiquitin-like peptide SUMO to substrate.
Sumoylation is critically implicated in multiple biological processes, including
cell proliferation, differentiation, senescence and apoptosis, etc. Therefore, it
is not surprising that dysregulation of sumoylation has been implicated in
tumorigenesis and different types of cancer were found to be addicted to
functional sumoylation pathway. The potential role for sumoylation as a
therapeutic target in caner is emerging. In this review, we summarize current
knowledge regarding the involvement of sumoylation in genome stability and
DNA damage response. We will further discuss the therapeutic potential of
sumoylation as synthetic lethal partner and as a key signaling pathway in cancer stem cells.
Keywords: Sumoylation, genome stability, DNA damage response, synthetic lethality, cancer stem cell.
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