Sumoylation in Cellular Senescence and Aging

Author(s): L. Gong, Q. Sun, D. W.-C. Li.

Journal Name:Current Molecular Medicine

Volume 16 , Issue 10 , 2016

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Abstract:

Sumoylation is a reversible post-translational modification that conjugates small peptide SUMO (small ubiquitin-like modifier) to a target protein. Global protein sumoylation and expression of components in sumoylation pathway were recently found to be altered in the process of organismal aging. In addition, key factors controlling cellular senescence are known to be sumoylated. This review will summarize current information on the function of sumoylation in cellular senescence and aging.

Keywords: Sumoylation, p53, RB, senescence, aging.

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Article Details

VOLUME: 16
ISSUE: 10
Year: 2016
Page: [871 - 876]
Pages: 6
DOI: 10.2174/1566524016666161223104915
Price: $58