Protein bioconjugates can be synthesized by using chemical reactions, enzymatic reactions
or genetic engineering technologies. Naturally occurred protein fusion event is used on purpose in the
development of better biopharmaceuticals by applying genetic engineering methodologies. This review
will mainly focus on the types of fusion proteins produced with the use of recombinant DNA
technology, by combining genes or parts of genes from the same or different organisms, in order to be
used in pharmaceutical applications for several purposes. Main concerns for the development of better
biopharmaceuticals include quality, efficacy, safety, immunogenicity and toxicity issues. Extending
half-life of the drug to increase patient compliance, targeting the drugs to reduce toxicity, improving
the manufacturing environment to reduce the costs and revealing protein interaction technologies
to find novel and superior drugs are the main aims of fusion protein production. Here, related tags and
examples of fusion methods for different purposes will be explained precisely.
Keywords: Antibodies, Bioconjugates, Engineered protein, Fc fusion, Fusion proteins, Half-life extension, Targeting.
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