Dendritic nanomaterials have attracted a great deal of scientific interest due to their high
capacity for multifunctionalization and potential in various biomedical applications, such as
drug/gene delivery and diagnostic systems. Depending on the molecular structure and starting monomers,
several different types of dendrimers have been developed, including poly(amidoamine)
(PAMAM), poly(propylenimine) (PPI), and poly(L-lysine) (PLL) dendrimers, in addition to modified
dendritic nanomaterials, such as Janus dendrimers and dendritic block copolymers. The chemical
structure and surface modification of dendritic nanomaterials have been found to play a critical role in
governing their biological behaviors. In this review, we present a comprehensive overview focusing
on the synthesis and chemical structures of dendrimers and modified dendritic nanomaterials that are
currently being investigated for drug delivery, gene delivery, and diagnostic applications. In addition,
the impact of chemical surface modification and functionalization to the dendritic nanomaterials on
their therapeutic and diagnostic applications are highlighted.
Keywords: Dendrimers, Dendrons, Dendritic nanomaterials, Drug delivery, Gene delivery, Diagnostics.
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