Background: Endometriosis is a disease common among women of reproductive age
characterized by pain, anxiety and infertility. Defined as the growth of endometrial tissue in ectopic
locations, endometriosis remains an enigmatic disease for which current treatments are less than ideal.
Much of these shortcomings to current therapy stem from our incomplete understanding on the
pathogenesis of the disease. It is generally accepted that endometriosis is an estrogen-dependent
disease and, as such, the majority of treatment approaches aim at reducing estrogen action and/or
production. Unfortunately, this approach is not effective in all women with endometriosis and in those
women where success is achieved with their use, there is potential for health-comprising side effects.
Objective: The objective of this review is to summarize current approaches for treatment of
endometriosis, discuss their limitations and potential reasons for lack of progress towards better
therapeutics for this disease.
Results: In this review we summarize the current approaches for treatment of endometriosis, discuss
their limitations and potential reasons for lack of progress towards better therapeutics for this disease.
Conclusion: Based upon the current state of knowledge, there is a strong necessity for through
assessment at the level of the genome, miRNAome and proteome as well as the importance of
integrating clinically-relevant endpoints in future studies which evaluate potential endometriosis
therapies in experimental models of endometriosis.