Metabolomics as a Functional Tool in Screening Gastro Intestinal Diseases: Where are we in High Throughput Screening?
Hamilton M. Ishiki,
Nagendra Sastry Yarla,
Sócrates Golzio dos Santos,
Mateus Feitosa Alves,
José Maria Barbosa Filho,
Margareth F. F. M. Diniz,
Marcus T. Scotti,
Identifying novel bio markers in gastro intestinal disease is a promising method where a
comprehensive analysis of the metabolome is performed. Metabolomics has evolved enormously in
the past decade, paving a path in gastro intestinal disease research, especially diseases which lead to
high morbidity and mortality. Metabolomics involves identifying metabolites such as anti-oxidants,
and amino acids etc., which are screened in the urine, feces and tissue samples. Certain cases employ
advanced tools like GC-MS, 1HNMR and GC–MS/SPME which reveal valuable information
concerning disease severity and differentiation. In light of escalating health care costs and risky
invasive procedures, metabolomics can be chosen as a safe yet precise method for screening diseases
like ulcerative colitis, Crohns’ disease, celiac disease, and gastro intestinal cancers. The present
review focuses on major advancements in gastro intestinal metabolomics, giving attention to which
parameters are assessed, and to recent changes in metabolite analysis.
Keywords: Metabolomics, gastrointestinal disorders, analysis, metabolites, Ulcerative colitis, Crohns’ disease, Celiac disease,
inflammatory bowel disease.
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