Combinatorial Chemistry & High Throughput Screening

Rathnam Chaguturu 
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Metabolomics as a Functional Tool in Screening Gastro Intestinal Diseases: Where are we in High Throughput Screening?

Author(s): Rohit Gundamaraju, Ravichandra Vemuri, Rajaraman Eri, Hamilton M. Ishiki, Ericsson Coy-Barrera, Nagendra Sastry Yarla, Sócrates Golzio dos Santos, Mateus Feitosa Alves, José Maria Barbosa Filho, Margareth F. F. M. Diniz, Marcus T. Scotti, Luciana Scotti.

Abstract:

Identifying novel bio markers in gastro intestinal disease is a promising method where a comprehensive analysis of the metabolome is performed. Metabolomics has evolved enormously in the past decade, paving a path in gastro intestinal disease research, especially diseases which lead to high morbidity and mortality. Metabolomics involves identifying metabolites such as anti-oxidants, and amino acids etc., which are screened in the urine, feces and tissue samples. Certain cases employ advanced tools like GC-MS, 1HNMR and GC–MS/SPME which reveal valuable information concerning disease severity and differentiation. In light of escalating health care costs and risky invasive procedures, metabolomics can be chosen as a safe yet precise method for screening diseases like ulcerative colitis, Crohns’ disease, celiac disease, and gastro intestinal cancers. The present review focuses on major advancements in gastro intestinal metabolomics, giving attention to which parameters are assessed, and to recent changes in metabolite analysis.

Keywords: Metabolomics, gastrointestinal disorders, analysis, metabolites, Ulcerative colitis, Crohns’ disease, Celiac disease, inflammatory bowel disease.

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Article Details

VOLUME: 20
ISSUE: 3
Year: 2017
Page: [247 - 254]
Pages: 8
DOI: 10.2174/1386207319666161220122903
Price: $58