Globulins are a major class of seed storage proteins which were thought to be enzymatically
inactive. These proteins belong to the most ancient cupin superfamily. They can be graded into
11S legumin type and 7S vicilin type based on their sedimentation coefficients. Members from both
classes share structural homology are thought to have evolved from either one-domain germin predecessor
by duplication or by horizontal gene transfer of two-domain gene from bacteria to eukaryotes.
Globulins are known to define the nutritional quality of the seeds, however, they are also involved in
sucrose binding, desiccation, defense against microbes, hormone binding and oxidative stress etc.
Major drawback with globulins is their tendency to bind to IgE. Studying structural-functional behavior
of such protein can help in modifying proteins for enhanced functionality in food processing
Keywords: Globulins, cupin superfamily, 7S vicilin, 11S legumin, evolution, seed storage protein.
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