Sodium channel blocker insecticides (SCBIs) are a relatively new class of insecticides
that are represented by two commercially registered compounds, indoxacarb and
metaflumizone. SCBIs, like pyrethroids and DDT, target voltage-gated sodium channels
(VGSCs) to intoxicate insects. In contrast to pyrethroids, however, SCBIs inhibit VGSCs at a
distinct receptor site that overlaps those of therapeutic inhibitors of sodium channels, such as
local anesthetics, anticonvulsants and antiarrhythmics. This review will recount the development
of the SCBI insecticide class from its roots as chitin synthesis inhibitors, discuss the
symptoms of poisoning and evidence supporting inhibition of VGSCs as their mechanism of
action, describe the current model for SCBI-induced inhibition of VGSCs, present a model for
the receptor for SCBIs on VGSCs, and highlight differences between data collected from
mammalian and insect experimental models.
Keywords: Voltage-gated sodium channels, sodium channel blocker insecticides, metaflumizone, indoxacarb, statedependent
channel block, insecticide receptors.
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