Current Drug Targets

Francis J. Castellino
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
Dean Emeritus, College of Science
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556
USA

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Targeting Legumain As a Novel Therapeutic Strategy in Cancers

Author(s): Chun-Wai Mai, Felicia Fei-Lei Chung, Chee-Onn Leong.

Graphical Abstract:


Abstract:

Background: Recent reports indicate that the tumor microenvironment plays a pivotal role in cancer development and progression, leading to a paradigm shift in the way cancer is studied and targeted. In contrast to traditional approaches, where only tumor cells are targeted for the treatment, an emerging approach is to develop therapeutics which target the tumor microenvironment while complementing or enhancing current treatments. Legumain (LGMN) is a newly identified target which is highly expressed in the tumor microenvironment and in tumor cells, and holds potential both as a biomarker and as a therapeutic target.

Conclusion: This review will be the first to summarize the expression of LGMN in common cancers, as well as its roles in tumorigenesis and metastasis. This review also discusses the current developments and future prospects of targeting LGMN through the development of DNA vaccines, azopeptides, small molecule inhibitors and LGMN activated prodrugs, highlighting the potential of LGMN as a target for cancer therapeutics.

Keywords: Legumain, cancer, tumor microenvironment, vaccine, azo-peptide, small molecules, prodrug.

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Article Details

VOLUME: 18
ISSUE: 11
Year: 2017
Page: [1259 - 1268]
Pages: 10
DOI: 10.2174/1389450117666161216125344
Price: $58