Background: Despite being known for their antibacterial activity, the oxazolidines are molecules
with wide pharmacological action and may act as anticonvulsants, anti-inflammatory and antineoplasic
agents. However, such activities have been poorly explored and only two oxazolidinic derivatives
hit the market until now. Therefore, this review covers the main biological activities of oxazolidines,
indicating which of the classes and substituents have the best biological results as well as the synthesis
methodology used to obtain them.
Methods: The search for bibliographic data was made using a question focused on the oxazolidine structure
and their respective activities, besides using inclusion/exclusion criteria clearly defined. The selected
papers were subjected to qualitative content analysis methodology to be used in this review.
Results: The oxazolidines remain excellent candidates for antibacterial, presenting three compounds in
clinical testing phase (Radezolide, Cadezolide and Sutezolide), besides being a good candidate as antitubercular
agents. Other less explored activities have niches with a great therapeutic potential such as
the oxazolidines acting on 5-HT receptors (anticonvulsant) and Zolmitriptan (anti-migraine), and also
mefloquine-oxazolidine derivatives which may act as antineoplasic and antitubercular agents.
Conclusion: This review summarizes the versatility and great therapeutic potential that oxazolidines can
offer, reinforcing the need for further studies and investments for this class of molecules.