The Role of Carbonic Anhydrase in Hepatic Glucose Production (E-pub Ahead of Print)
Ibrahim Salihu Ismail.
Considerable efforts are being made daily to discover novel therapeutic targets to better understand the mechanism for designing drugs in treating diabetes. Inhibition of hepatic gluconeogenesis by metformin remains the first line of oral therapy for managing type 2 diabetes. The link between rise in blood lactate level and reduction of hepatic glucose production with metformin usage remains to be determined. Carbonic anhydrase is proposed to be the link connecting blood lactate accumulation and inhibition of hepatic gluconeogenesis and thus could serve as a new therapeutic target for reducing hepatic glucose production. Understanding the link between rise in blood lactate level and the role of carbonic anhydrase in lactate uptake will be essential towards the development of a promising new antidiabetic medication.
Keywords: Type 2 diabetes, Carbonic anhydrase, Gluconeogenesis, lactate, Metformin, Therapy
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