Background: Deficits in cholinergic neurotransmission due to the degeneration of
cholinergic neurons in the brain are believed to be one of the major causes of the memory
impairments associated with AD. Targeting acetyl cholinesterase (AChE) surfaced as a potential
therapeutic target in the treatment of Alzheimer's disease. The present study is pursued to develop
quantitative structure activity relationship (QSAR) models to determine chemical descriptors
responsible for AChE activity.
Methods: Two different sets of AChE inhibitors, dataset-I (30 compounds) and dataset-II (20
compounds) were investigated through MLR aided linear and SVM aided non-linear QSAR models.
Results: The obtained QSAR models were found statistically fit, stable and predictive on validation
scales. These QSAR models were further investigated for their common structure-activity relationship
in terms of overlapping molecular descriptors selection. Atomic mass weighted 3D Morse descriptors
(MATS5m) and Radial Distribution Function (RDF045m) descriptors were found in common SAR
for both the datasets. Electronegativity weighted (MATS5e, HATSe, and Mor17e) descriptors have
also been identified in regulative roles towards endpoint values of dataset-I and dataset-II.
Conclusion: The common SAR identified in these linear and non-linear QSAR models could be
utilized to design novel inhibitors of AChE with improved biological activity.