Pediatric cancer has undergone significant improvements in survival over the past several
decades, in part due to a better understanding of the underlying genetic aberrations of each oncologic
diagnosis, which has allowed for more effective targeted therapies. Pediatric brain tumors,
leukemia, lymphoma, Wilms tumor, and retinoblastoma are exemplary pediatric cancers that each
has specific epidemiology regarding children at risk as well as characteristic associated genetic lesions.
These genetic features are more commonly being used to provide risk stratification, as well
as to identify novel pathways for targeted therapy. With these advances, the overall survival of pediatric
cancers continues to be improved.
Keywords: Brain tumors, cancer, genetics, leukemia, lymphoma, pediatrics, retinoblastoma, wilms tumor.
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