Background: Polyethylene Glycols (PEGs) or macrogols are reputed to be inert and nonimmunogenic
substances, however they are reported to induce immediate type hypersensitivity reactions.
Due to their widespread use in extensively consumed products as cosmetics and drugs, the attention
towards these substances is still low.
Conclusion: Therefore, it may be useful to focus clinician's attention on possible adverse reactions
caused by these polymers.
Keywords: Anaphylaxis, excipients, hypersensitivity, immediate-type reaction, macrogols, polyethylene glycols.
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