DARPins Bioengineering and its Theranostic Approaches: Emerging Trends in Protein Engineering

Author(s): Mahmood Rasool* , Arif Malik , Mubashir Hussain , Kalsoom A. Haq , Kiran Butt , Muhammad Abdul Basit Ashraf , Muhammad Imran Naseer , Muhammad Asif , Rozena Shaikh , Mohammad Zahid Mustafa , Qamre Alam , Ghulam Rasool , Waseem Ahmad , Absarul Haque , Mohammad Amjad Kamal .

Journal Name: Current Pharmaceutical Design

Volume 23 , Issue 11 , 2017

Abstract:

The therapeutic significance of bioengineering proteins has increased dramatically as a new generation of pharmacological drug with a great potential in medical treatment. Protein engineering has improved the use of new non immunoglobulin affinity proteins. The designed ankyrin repeat proteins abbreviated as DARPins is a classical example. These molecules have smaller structural size, unlike immunoglobulins, but similar target affinity is of great significance. Such molecules get more binding specificity and greater thermodynamic stability. These attributes made DARPins a favorite player in diagnostics and therapeutics of cancer. How DARPins are improved into vigorous and versatile scaffold for binding protein and selected by ribosome and phage display along with related aspects is discussed in this review.

Keywords: Designed ankyrin repeat proteins, Protein bioengineering, Therapeutics.

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Article Details

VOLUME: 23
ISSUE: 11
Year: 2017
Page: [1610 - 1615]
Pages: 6
DOI: 10.2174/1381612822666161208121829
Price: $58

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