Frontiers in Clinical Drug Research: Diabetes and Obesity

Volume: 3

"Frontiers in Clinical Drug Research – Diabetes and Obesity is an eBook series that brings updated reviews to readers interested in advances in the development of pharmaceutical agents for the ...
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The Growth Hormone/Insulin-like Growth Factor System in the Management of Diabetes and Obesity

Pp. 59-80 (22)

Moira S. Lewitt

Abstract

It is well recognised that the growth hormone (GH)/insulin-like growth factor (IGF) system is well recognised to have a role in diabetes and obesity. The IGFs (IGF-I and IGF-II) have structural similarity to proinsulin and the type 1 IGF receptors and insulin receptors are able to form heterodimers that participate in metabolic and mitogenic signalling. Obesity, diabetes and the metabolic syndrome are associated with alterations in the GH/IGF system. Perturbations in this system are also associated with predisposition to diabetes, obesity and the metabolic syndrome and also the risk of vascular and other complications.

Targeting this system holds therapeutic promise. Therefore, having introduced the relevant physiology and pathophysiology, the evidence base in to using GH and IGFs in the management of GH and IGFs therapy will be presented and the advantages and limitations of such approaches will be discussed.

Keywords:

Diabetes mellitus, Growth hormone, Insulin-like growth factor-I, Insulin-like growth factor-binding protein-3, Insulin resistance, Obesity.

Affiliation:

School of Health Nursing and Midwifery, University of the West of Scotland, Paisley PA1 2BE, Scotland, UK.