Design and Synthesis of 1,4-dihydropyridine Derivatives as Anti-cancer Agent

Author(s): Denish Viradiya , Sheefa Mirza , Faraz Shaikh , Rajesh Kakadiya* , Anand Rathod , Nayan Jain , Rakesh Rawal* , Anamik Shah* .

Journal Name: Anti-Cancer Agents in Medicinal Chemistry

Volume 17 , Issue 7 , 2017

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Abstract:

Aims: A series of 1,4-dihydropyridine based compounds bearing benzylpyridinium moiety have been designed and evaluated for in vitro anticancer activity against glioblastoma U87MG, lung cancer A549 and colorectal adenocarcinoma Caco-2 cell lines using the MTT assay.

Method: Among these compounds, 7b, 7d, 7e, and 7f exhibited potent anticancer activity against the cell lines tested. The cytotoxicity of the synthesized derivatives was compared to standard drugs (carboplatin, gemcitabine, and daunorubicin).

Result: Thus, synthesized 1,4-dihydropyridines can be considered as the encouraging molecules for further drug development as anticancer agents.

Keywords: Anticancer activity, antipoliferative activity, benzylpyridinium salt, 1, 4-dihydropyridine, MTT assay.

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Article Details

VOLUME: 17
ISSUE: 7
Year: 2017
Page: [1003 - 1013]
Pages: 11
DOI: 10.2174/1871520616666161206143251
Price: $58

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