Background: In the present study, a series of substituted phenyl β,β-diphenylpropanoate
were synthesized by the reaction of β,β-diphenylpropionyl chloride with various substituted phenols in
Methods: Upon synthesis of compounds, the characterization of synthesized compounds was made
using IR, NMR, Mass spectroscopy and elemental anaysis. These derivatives were screened for analgesic
activity and anti-inflammatory activity (Carrageen induced paw edema method) Diclofenac sodium
and Indomethacin were used as standard drug for analgesic activity and anti-inflammatory response,
Results: The compounds 2-nitro Phenyl 3,3 diphenyl propionate (HD-5) and 4-nitro Phenyl 3,3
diphenyl propionate (HD-2) exhibited significantlly potent anti-inflammatory and analgesic activity
(two to three times) when comparision was made with control group. The response of promising compound
(HD-5) for analgesic and anti-inflammatory action was highest among all the test compound and
was almost similar to the standard compounds (Indomethacin and Diclofenac Sodium).
Conclusion: The findings of present work confirm the potent action of HD-5 compounds as analgesic
and anti-pyretic in experimental animals.