Synthesis of Some Novel Substituted Phenyl β, β-Diphenyl Propanoate with Analgesic and Anti-inflammatory Activity

Author(s): Harshita Dhall, Arvind Kumar, Arun K. Mishra*.

Journal Name: Current Bioactive Compounds

Volume 14 , Issue 1 , 2018

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Abstract:

Background: In the present study, a series of substituted phenyl β,β-diphenylpropanoate were synthesized by the reaction of β,β-diphenylpropionyl chloride with various substituted phenols in acetone.

Methods: Upon synthesis of compounds, the characterization of synthesized compounds was made using IR, NMR, Mass spectroscopy and elemental anaysis. These derivatives were screened for analgesic activity and anti-inflammatory activity (Carrageen induced paw edema method) Diclofenac sodium and Indomethacin were used as standard drug for analgesic activity and anti-inflammatory response, respectively.

Results: The compounds 2-nitro Phenyl 3,3 diphenyl propionate (HD-5) and 4-nitro Phenyl 3,3 diphenyl propionate (HD-2) exhibited significantlly potent anti-inflammatory and analgesic activity (two to three times) when comparision was made with control group. The response of promising compound (HD-5) for analgesic and anti-inflammatory action was highest among all the test compound and was almost similar to the standard compounds (Indomethacin and Diclofenac Sodium).

Conclusion: The findings of present work confirm the potent action of HD-5 compounds as analgesic and anti-pyretic in experimental animals.

Keywords: Aryl propionic acid, analgesic activity, anti-inflammatory activity, ulceration, potency, biosynthesis.

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Article Details

VOLUME: 14
ISSUE: 1
Year: 2018
Page: [26 - 32]
Pages: 7
DOI: 10.2174/1573407213666161205161135

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