Synthesis of Some Novel Substituted Phenyl β, β-Diphenyl Propanoate with Analgesic and Anti-inflammatory Activity

Title:Synthesis of Some Novel Substituted Phenyl β, β-Diphenyl Propanoate with Analgesic and Anti-inflammatory Activity

Volume: 14 Issue: 1

Author(s): Harshita Dhall, Arvind Kumar and Arun K. Mishra*

Affiliation:

• Drug Design Laboratory, School of Pharmaceutical Sciences, IFTM University, Moradabad 244001, Uttar Pradesh,India

Keywords: Aryl propionic acid, analgesic activity, anti-inflammatory activity, ulceration, potency, biosynthesis.

Abstract: Background: In the present study, a series of substituted phenyl β,β-diphenylpropanoate were synthesized by the reaction of β,β-diphenylpropionyl chloride with various substituted phenols in acetone.

Methods: Upon synthesis of compounds, the characterization of synthesized compounds was made using IR, NMR, Mass spectroscopy and elemental anaysis. These derivatives were screened for analgesic activity and anti-inflammatory activity (Carrageen induced paw edema method) Diclofenac sodium and Indomethacin were used as standard drug for analgesic activity and anti-inflammatory response, respectively.

Results: The compounds 2-nitro Phenyl 3,3 diphenyl propionate (HD-5) and 4-nitro Phenyl 3,3 diphenyl propionate (HD-2) exhibited significantlly potent anti-inflammatory and analgesic activity (two to three times) when comparision was made with control group. The response of promising compound (HD-5) for analgesic and anti-inflammatory action was highest among all the test compound and was almost similar to the standard compounds (Indomethacin and Diclofenac Sodium).

Conclusion: The findings of present work confirm the potent action of HD-5 compounds as analgesic and anti-pyretic in experimental animals.

Cite this article as:

Dhall Harshita, Kumar Arvind and Mishra K. Arun*, Synthesis of Some Novel Substituted Phenyl β, β-Diphenyl Propanoate with Analgesic and Anti-inflammatory Activity, Current Bioactive Compounds 2018; 14 (1) . https://dx.doi.org/10.2174/1573407213666161205161135