Background: Sore throat sprays provide targeted relief by delivering the active ingredient
directly to the site of pain. Different sprays vary in characteristics, thus affecting delivery of the active ingredient
to the throat, which can impact compliance.
Objective: The characteristics and performance of FLURBIPROFEN 8.75 mg SPRAY were compared
with 12 other sprays.
Method: Parameters assessed included spray angle and pattern, droplet size distribution, shot weight uniformity
and shot weight throughout life.
Results: Among all sprays tested WICK Sulagil Halsspray had the smallest spray angle (46°) and also the
smallest diameter spray pattern (X=32.8 mm; Y=34.4 mm). Thiovalone®
Buccal Spray Suspension had
both the largest spray angle (82°) and largest diameter spray pattern (X=62.6 mm; Y=78.0 mm). Hasco
Sept® Aerosol Spray had the smallest droplet size (Dv90=118.4 μm) whereas OKi infiammazione e
0.16% spray had the largest (Dv90=214.34 μm). In terms of shot weight uniformity, TANTUM®
VERDE GOLA 0.25% spray showed the least variation (2% RSD) between shots and UNIBEN Aerosol
Spray the most (23.4% RSD). Shot weight throughout life studies showed that FLURBIPROFEN 8.75
mg SPRAY had the least deviation from shot weight (1.77%) whereas OKi infiammazione e dolore®
0.16% spray deviated the most (44.9%). FLURBIPROFEN 8.75 mg SPRAY had the second smallest
spray angle/pattern and droplet size distribution and also the least variation in shot weight.
Conclusion: Different sore throat sprays vary in different attributes, affecting delivery of the active ingredient.
FLURBIPROFEN 8.75 mg SPRAY performed well overall, ranking first among all sprays tested,
and providing a dose which is targeted and uniformly delivered throughout the life of the bottle.