Possible Molecular Mechanisms by which Vitamin D Prevents Inflammatory Bowel Disease and Colitis-associated Colorectal Cancer

Author(s): Zijian Luan, Yiming Ma, Yu Xin, Jiaming Qian*, Hongying Wang*.

Journal Name: Current Medicinal Chemistry

Volume 24 , Issue 9 , 2017

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Abstract:

It is well accepted that inflammatory bowel disease (IBD), including ulcerative colitis and Crohn’s disease, is one of high risk factors for colorectal cancer (CRC). This supports the notion that inflammation plays a key role in cancer development. Epidemiologic studies have shown that vitamin D (Vit D) deficiency is associated with IBD and various types of cancer including colorectal cancer. Clinical trials and mouse models have shown that Vit D is beneficial in preventing or ameliorating inflammation and carcinogenesis. Mechanism studies show that Vit D played wide-spectrum roles in anti-inflammation, immunoregulation, and anti-cancer activities. In this review, we summarized and updated the findings on Vit D, IBD and colitis-associated colorectal cancer (CAC) with the emphasis on the effects of Vit D on anti-inflammation, EMT and cancer stem cells (CSC).

Keywords: Vitamin D, IBD, colitis-associated colorectal cancer, inflammation, NF-κ B, EMT, cancer stem cell.

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Article Details

VOLUME: 24
ISSUE: 9
Year: 2017
Page: [911 - 917]
Pages: 7
DOI: 10.2174/0929867323666161202153028
Price: $58

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