Molecular, Cellular and Pharmaceutical Aspects of Synthetic Hydroxyapatite Bone Substitutes for Oral and Maxillofacial Grafting

Title:Molecular, Cellular and Pharmaceutical Aspects of Synthetic Hydroxyapatite Bone Substitutes for Oral and Maxillofacial Grafting

Volume: 18 Issue: 1

Author(s): Werner Gotz and Spyridon N. Papageorgiou

Affiliation:

Keywords: Biomaterials, synthetic bone substitutes, hydroxyapatite, osteoinduction, calcium phosphate, degradation.

Abstract: Bone grafts are widely used for augmentation procedures in oral and maxillofacial surgery, with autogenous bone being the gold standard. Recently, the focus of research has shifted towards synthetic bone substitutes, as no second surgery is needed and large quantities of graft can easily be provided. Within the broad range of bone substitutes, synthetic hydroxyapatite has drawn much attention, as they are considered to be biocompatible, non-immunogenic, osteoconductive and osteoinductive. Scope of this review is to summarize existing knowledge concerning the molecular, cellular and pharmaceutical aspects of synthetic bone substitutes for oral and maxillofacial grafting.

Cite this article as:

Gotz Werner and Papageorgiou N. Spyridon, Molecular, Cellular and Pharmaceutical Aspects of Synthetic Hydroxyapatite Bone Substitutes for Oral and Maxillofacial Grafting, Current Pharmaceutical Biotechnology 2017; 18 (1) . https://dx.doi.org/10.2174/1389201017666161202103218