Progress in the chemistry of cyclic enamino-nitriles based on the advanced synthetic methodologies
is reported. Due to the recent accomplishment, it becomes possible to reactivate these molecules
toward electrophiles, nucleophiles and as electron rich dienes in 2+3 dipolar additions and in
4+2 cycloadditions reactions. Synthesizing the poly functionalized 4H-pyrans and their fused derivatives
is a fascinating field with a multitude of biological implications such as antitumor, cardiotonic,
hepatoprotective, antihypertensive, antibronchitis, as well antifungal activity. This work was conducted
with particular emphasis on reviewing the work done on the cyclic enamines since 1990 up till
now in order to highlight in more details the synthetic pathways, interactions and the biological activities,
Furthermore; we referred to the recent original data of our group contributions within this field.
Keywords: Cyclic enamines, cycloaddition, electrophiles, nucleophiles, functionally substituted enamines, biological activity.
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