Background: Glucocorticoids (GCs) are largely used in different inflammatory,
autoimmune and proliferative diseases. To date their mechanism of action is not completely clear and
more studies are necessary, in particular to explain the great interindividual variability in clinical
response. In this panorama the glucocorticoid receptor (GR) has an important role: in fact it regulates
the pharmacological response thanks to the capability to interact with different molecules (DNA,
RNA, ncRNA and proteins) that are known to influence its activity.
Results: In this review our aim is to highlight the knowledge about the role of protein-protein, RNAprotein
interactions and epigenetic modifications on the GR and the consequent response to GCs. The
characteristics of these interactions with the GR and their effects on the pharmacological activity of
GCs will be examined.
Conclusion: This information could contribute to the prediction of individual sensitivity to steroids
through the identification of new markers of GC resistance. In addition this knowledge may be used in
developing new strategies for targeted therapy.