Background: Tooth loss occurs with age and significantly impacts the quality of elderly's
life both physically and psychologically. It has been well known that odontogenesis is a complicated
process with sequential and reciprocal interactions between epithelial and mesenchymal tissues and
different types of dental tissue-derived stem cells involve in it. However, only a small portion of the
intricate mechanisms has been defined nowadays. Among them, epigenetics has become an increasingly
important mechanism for tooth development and regeneration.
Objective: This review aims at illustrating the function of epigenetic regulation in odontogenesis, which
plays an important role in dental tissue-derived stem cell self-renewal and differentiation nowadays and
would be a new strategy for tooth regeneration.
Results: In this review, we introduced the natural process of tooth development and the functions of
stem cells involved in. Furthermore, we summarized the current knowledge on epigenetic regulation
including DNA methylation, histone modification, and non-coding RNAs during odontogenesis, providing
the theoretical basis for tooth regeneration.
Conclusion: Along with a deeper understanding of odontogenesis, the epigenetic mechanism involved
in has become increasingly important. Therefore, it’s necessary to further study the functions of epigenetic
regulation in tooth development and regeneration, which may make tooth regeneration a reality in