Enantiomeric Resolution of (RS)-Naproxen and Application of (S)- Naproxen in the Direct and Indirect Enantioseparation of Racemic Compounds by Liquid Chromatography: A Review

Author(s): Sonika Batra, Ravi Bhushan*.

Journal Name: Current Medicinal Chemistry

Volume 24 , Issue 8 , 2017

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Graphical Abstract:


(S)-Naproxen (Npx), an α-aryl propionic acid derivative, belongs to the class of Non-Steroidal Anti-Inflammatory Drugs and is easily available in pure (S)-form. (S)-Npx has been used as a chiral selector for chromatographic separation of a variety of racemates, using both direct and indirect methods, and has been found to be useful and successful as a basic chiral moiety. This review article describes methods for enantioseparation of (RS)-Npx, development of chiral stationary phases based on (S)-Npx and preparation of novel chiral derivatizing reagents synthesized from (S)-Npx along with their application for enantioseparation of several pharmaceutically important racemates.

Keywords: (S)-Naproxen, liquid chromatography, chiral derivatizing reagents, chiral stationary phase, enantioseparation, racemic pharmaceuticals.

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Article Details

Year: 2017
Page: [758 - 780]
Pages: 23
DOI: 10.2174/0929867323666161129093052
Price: $58

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PDF: 32