In HCV genome, the NS5B RNA-dependent RNA polymerase (RdRp) plays central role in
the replication. It is the most preferred target for design and screening of small molecule HCV inhibitors.
From in house compound library screening using NS5B polymerase enzymatic assay, we identified
some benzimidazole derivatives. The activities were predicted using the QSAR generated models.
Along with QSAR predictions, molecular docking studies help to study binding of these series of compounds
at allosteric pocket (AP-1).
Keywords: Benzimidazole derivatives, anti-HCV agents, NS5B polymerase inhibitors, molecular docking.
Rights & PermissionsPrintExport