Background: Croton bonplandianum is an important medicinal plant and widely
used in Indian system of medicine to heal cuts and wounds. However, systematic evaluation
of wound healing activity of C. bonplandianum is lacking.
Objectives: The present study was aimed to assess the wound healing activity of different
parts of C. bonplandianum herbal preparations.
Method: Wistar albino rats of both sexes were selected and divided into five groups, viz, untreated
control, wounded rats treated with herbal preparations from leaf (CBLf), fruit (CBFt)
and latex (CBLx) of C. bonplandianum and α-tocopherol. The collagen content in tissue and
wound contraction rate was analysed. The levels of lipid peroxidation and antioxidant enzymes
like superoxide dismutase (SOD) and catalase (CAT) in serum and granulation tissue
Results: The increased levels of collagen content and wound contraction rate were observed
in CBLf, CBFt and CBLx treated rats when compared with untreated control group. Increased
levels of superoxide dismutase (SOD) and catalase (CAT) and reduced level of lipid
peroxidation were found in both serum and granulation tissue of wounded rats treated with
CBLf, CBFt and CBLx. The wounded rats treated with CBLx showed more antioxidant activity,
significant wound contraction rate and higher level of collagen content when compared
to CBLf and CBFt treated rats.
Conclusion: The results suggested that the CBLx treated rats showed maximum percentage
of healing activity than CBLf and CBFt treated rats. The results of this study supported that
the traditional claims of C. bonplandianum latex as a wound healer.