Pp. 210-259 (50)
Yunhua Gao, Yuqin Qiu and Suohui Zhang
Transdermal drug delivery is a well-accepted route of administration for
therapeutical drugs. Skin is the largest area human body organ, however, the substantial
barrier property of the skin stratum corneum limits practical value of transdermal route
of drug administration. It has been proved that microneedle array devices can overcome
the barrier characteristics of the stratum corneum and enhance the delivery of
therapeutic medicines through skin. This chapter focuses on looking at the
microneedle-mediated transdermal drug delivery for therapeutical applications. The
definition of microneedles, enhancement mechanisms and devices in research or in the
market are also depicted.
Definition, Devices in research or in the market, Mechanisims of
action, Microneedle, Therapeutical applications.
Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.