Physical Penetration Enhancers: An Overview
Pp. 3-34 (32)
Isabel Marlen Rodríguez-Cruz, Clara Luisa Domínguez-Delgado, José Juan Escobar-Chávez, Miriam López-Cervantes and Roberto Díaz-Torres
A number of physical methods for drug penetration enhancement and
improve bioavailability of the stratum corneum (SC) such as micro-needles, heating,
iontophoresis, electroporation, and ultrasound have also been evaluated in the last
decade. On the other hand, nanotechnology has shown remarkable potential in targetspecific
delivery of drugs in the body. In this chapter, we discuss the role of overview
about nanocarrier systems, physical enhancers and their possible combination in order
to improve the passage of molecules through the organ systems. All these methods
have their own advantages and disadvantages, nevertheless, novel developments are
projected to be more adaptable to different needs.
Controlled release, Drug delivery, Nanocarrier systems,
Nanomedicine, Nanoparticles, Nanopharmaceutics, Physical penetration
enhancers, Synergism, Therapeutic applications.
Hospital Regional de Alta Especialidad de Zumpango. Unidad de Enseñanza e Investigación, Zumpango, Estado de México. C.P.56600, México; & Laboratorio de Investigación en Citogenética Básica del CBT Dr. Alfonso León de Garay. Calle Fresnos S/N, San Mateo, Tequixquiac, Estado de México C.P.55657, México.