Background: Prazequantel (Prz) is an important medication in humans and animals. It acts
against a number of pathogens. In this study, Prz nanoemulsion (PrzNE) was prepared and evaluated
for toxic, cytotoxic and mutagenic potentials.
Materials and Methods: The cytotoxic effect of PrzNE was observed in Artemia salina and Allium
cepa, while toxicity and mutegenicity in A. cepa test system. Potassium di-chromate (K2Cr2O7) and
copper sulphate (CuSO4.5H2O) were taken as standards for A. salina and A. cepa test, respectively.
Results: PrzNE at 16 µM caused 100% mortality of the brine shripms. It exerted a concentrationdependent
toxic and cytotoxic effects in A. cepa and A. salina. In comparison to the CuSO4.5H2O,
PrzNE produced less chromosomal aberrations (CA), where chromosomal fragments/loose and bridges
were most frequently observed.
Conclusion: PrzNE may readily cross the cell membranes of A. cepa and A. salina, increase the permeability
of the cell membrane and/or exert an oxidative stress, thus causes a cytotoxic effect. The PrzNE
was more cytotoxic than mutagenic in nature.