Non-Clinical Screening of Cyto-Genotoxicologic Status of Praziquantel Nanoemulsion

Author(s): Muhammad T. Islam*, Leticia Streck, Samara W.C. Silva, Ana M.O.F. da Mata, Marcus V.O.B. de Alencar, Ricardo M. de Carvalho, Arnobio A. da Silva-Junior, Ana A.C. Melo-Cavalcante.

Journal Name: Current Bioactive Compounds

Volume 14 , Issue 1 , 2018

Become EABM
Become Reviewer

Graphical Abstract:


Abstract:

Background: Prazequantel (Prz) is an important medication in humans and animals. It acts against a number of pathogens. In this study, Prz nanoemulsion (PrzNE) was prepared and evaluated for toxic, cytotoxic and mutagenic potentials.

Materials and Methods: The cytotoxic effect of PrzNE was observed in Artemia salina and Allium cepa, while toxicity and mutegenicity in A. cepa test system. Potassium di-chromate (K2Cr2O7) and copper sulphate (CuSO4.5H2O) were taken as standards for A. salina and A. cepa test, respectively.

Results: PrzNE at 16 µM caused 100% mortality of the brine shripms. It exerted a concentrationdependent toxic and cytotoxic effects in A. cepa and A. salina. In comparison to the CuSO4.5H2O, PrzNE produced less chromosomal aberrations (CA), where chromosomal fragments/loose and bridges were most frequently observed.

Conclusion: PrzNE may readily cross the cell membranes of A. cepa and A. salina, increase the permeability of the cell membrane and/or exert an oxidative stress, thus causes a cytotoxic effect. The PrzNE was more cytotoxic than mutagenic in nature.

Keywords: Cytotoxicity, mutagenicity, praziquantel nanoemulsion, enzymes, hypotension, budding parenchyma.

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 14
ISSUE: 1
Year: 2018
Page: [33 - 38]
Pages: 6
DOI: 10.2174/1573407213666161121162753

Article Metrics

PDF: 30
HTML: 5
EPUB: 1
PRC: 1