Background: In continuation of our research on sonochemistry and due to the importance
and application of hydrazones and N-acylhydrazones in drug discovery, in this work we report a new
general and efficient synthesis of these classes with different aromatic and heteroaromatic nucleus
assisted by ultrasound and their respective anti-tuberculosis and anti-cancer activities.
Method: Derivatives 7-chloroquinoline 10 and 12 were the most promising compounds against
cancer and TB, respectively.
Conclusion: Unfortunately all new hydrazones and N-acylhydrazones evaluated displayed no
activity anti cancer and TB.
Keywords: Hydrazones, N-acylhydrazones, sonochemistry, anti-tuberculosis and anti-cancer activities, drug discovery.
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