Background: Despite the large number of publications in the synthesis of heterocyclic compounds
based on unsaturated lactones, there are no systematic and modern data's on 3-arylmethylidene-
3H-furan-2-ones. These compounds are convenient starting materials for the synthesis of azaheterocycles
and are of independent interest as biologically active compounds. This review examines the interaction
of (3H) furan-2-ones with a variety of N-nucleophiles.
Methods: A systematic search of published data on the interaction of (3H) furan-2-ones with a variety
of N-nucleophiles was done. All the information collected was analyzed for quality and reliability.
Results: 55 articles were analyzed, of which more than 50% of the articles over the past 15 years.
Conclusion: It was shown, that 3-arylmethylidene-3H-furan-2-ones are available as substrates for construction
of heterocyclic systems with large preparative capabilities. A wide range of heterocycles has
been synthesized, which are promising for further studies as both synthons for fine organic synthesis
and substrates for the design of new biologically active compounds.