Autism is characterized by communication impairments, neurobehavioral, social abnormalities
and immunological and metabolic dysfunction. Among these, gastrointestinal abnormalities
are of clinical importance associated with the autistic individuals. Gastrointestinal abnormalities can
affect the neuropathological and behavioral features and contribute to pathogenesis of autistic symptoms.
Now a spate of new studies supports this notion and suggests that restoring proper microbial
balance could alleviate some of the disorder's behavioral symptoms. Evidence is mounting that some
of the beneficial intestinal microbiome called probiotics favors the individuals with autism supporting
the gut-brain barrier. These probiotics may provide therapeutic strategies for neurodevelopmental
disorders. Therapies that target the gut microbiome may hold the key for making progress against a
wide range of notoriously difficult psychiatric illnesses. Thus, a probiotic supplementation early in
life may reduce the risk of neuropsychiatric disorder development later in childhood possible by
mechanisms not limited to gut microbiota composition.
Keywords: Gut-brain barrier, microbiome, autistic symptoms, probiotic supplementation.
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