Glycogen phosphorylase (GP) is a validated pharmaceutical target for the development
of antihyperglycaemic agents. Phytogenic polyphenols, mainly flavonoids and pentacyclic
triterpenes, have been found to be potent inhibitors of GP. These compounds have both
pharmaceutical and nutraceutical potential for glycemic control in diabetes type 2. This review
focuses mainly on the most successful (potent) of these compounds discovered to date.
The protein-ligand interactions that form the structural basis of their potencies are discussed,
highlighting the potential for exploitation of their scaffolds in the future design of new GP
Keywords: Alpha-glucosidases, antioxidants, diabetes, glycogen phosphorylase, flavonoids, pentacyclic triterpenes.
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