Background: Ischemic stroke is the third leading cause of death and the most frequent cause
of permanent disability in adults worldwide. Tremendous advances have been made in understanding
of the pathophysiology of cerebral ischemia. Nevertheless, there is still no effective neuroprotectant
available in the clinical work. Recently, osteopontin (OPN), a glycophosphoprotein, has attracted more
attention due to its various effects in cardiovascular and nervous system diseases.
Objective: The aim of present review was to summarize recent findings about neuroprotective
effects of OPN on ischemic stroke, targeting to provide a novel therapeutic strategy.
Methods: To prepare this review, a pathophysiological and pharmacological literature survey was performed
using PubMed, and Web of Science. Also, some statistical and epidemiological literature
sources were used.
Results: Mounting evidence indicates that OPN attenuates cerebral damage and promotes neurogenesis
in ischemic stroke by binding to its receptors to activate diverse signaling pathways.
Conclusion: The paper highlights the neuroprotective and pro-regenerative effects of OPN after cerebral
ischemia, which would demonstrate its therapeutic potential in ischemic stroke and other informs
of ischemic brain injury.