Background: A straightforward protocol for the one-pot synthesis of a series of novel thiazolopyrimidine
derivatives has been developed.
Method: In which multicomponent reaction between thiobarbituric acid, 2-aminothiozole and several
substituted aldehydes using sulfamic acid (20 mol%) as a heterogeneous and easily recoverable catalyst
in ethanol under reflux condition.
Conclusion: This method has several advantages like greener synthetic approach, good to excellent
yield (82-91%), cost-effectiveness, easy work-up and atom-economic procedure.
Keywords: 2-Aminothiazole, 2-thiobarbituric acid, thiazolopyrimidine derivatives, sulfamic acid, atom economy, multicomponent
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