Aim: Sulphasalazine (SSZ), an anti-inflammatory drug, has been widely used
as a second line agent for Rheumatoid Arthritis. In this study Nanoprecipitation technique
and Ionic gelation techniques were selected for the preparation of Sulphasalazine nanoparticles.
Eudragit S100 and Ethyl Cellulose polymers were selected for nanoprecipitation
technique and chitosan was chosen as a polymer for inotropic gelation method. A comparative
study was performed.
Methods: Sulphasalazine loaded Eudragit S100 and Ethyl Cellulose nanoparticles were
prepared in five ratios varying the concentration of drug and polymer. Sulphasalazine
loaded Chitosan- Tripolyphosphate nanoparticles were prepared by Ionic gelation technique
in six ratios by varying the concentration of tripolyphophate solution as well as the
concentration of the drug.
Results: In nanoprecipitation technique, Out of the five formulations of EC and five formulations
of Eudragit, F3 formulation of EC showed promising results with mean particle
diameter of 165.3 nm and zeta potential of -47.7 mV with cumulative drug release of
97.89% in 12 h. In Ionic gelation method, out of six formulations, F6 formulation with
0.5% TPP and 4.687 mg/ml drug was considered as the best formulation because of its
good stability(-43.8mV) and mean particle diameter (147.9 nm) which produced a sustained
drug release of 97.92% in 12 h.
Conclusion: On comparing the best formulations of both the techniques, nanoprecipitation
was found to be the best technique because of its mean particlediameter (165.4 nm),
greater stability (-47.7 mV) and higher drug entrapment efficiency (89.29%).