The Chemistry of the Canthin-4-ones

Author(s): Franz Bracher*, Tim Tremmel.

Journal Name: Mini-Reviews in Organic Chemistry

Volume 14 , Issue 2 , 2017

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Graphical Abstract:


Background: The canthin-4-ones are a small, yet underexplored class of natural products from Apocynaceae plants. Efficient synthetic approaches are required for exploring this class of natural products for drug discovery.

Objective: In this review, the synthetic approaches towards these alkaloids, as well as synthetic analogues are summarized comprehensively. Further, the applications of canthin-4-ones as building blocks for the synthesis of alkaloids and other polycyclic compounds of pharmaceutical interest are demonstrated.

Conclusion: Meanwhile, efficient and flexible approaches to the canthin-4-one scaffold are available which should foster in-depth investigation of this chemotype for drug development.

Keywords: Canthin-4-ones, alkaloids, total synthesis, β-carbolines, ring transformation, biological activity.

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Article Details

Year: 2017
Page: [92 - 98]
Pages: 7
DOI: 10.2174/1570193X14666161110114103
Price: $65

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