Hypersensitivity Reactions from Excipients in Systemic Glucocorticoid Formulations

Author(s): Gianfranco Calogiuri, Lene H. Garvey, Paolo Romita, Luigi Macchia, Caterina Foti.

Journal Name: Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents)

Volume 15 , Issue 2 , 2016

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Abstract:

Glucocorticoids are the most widely used drugs for the treatment of hypersensitivity, however these drugs themselves and the excipients contained in commercial corticosteroid formulations are able to induce severe immediate-type hypersensitivity reactions. Reactions involving excipients have been confirmed to be IgE mediated by the demonstration of specific-IgE to excipients such as carboxymethylcellulose and lactose. In case of hypersensitivity reactions to corticosteroid preparations, a complete allergy work-up with skin tests and/or challenge tests should include testing excipients as well as the active ingredients.

Keywords: Anaphylaxis, carboxymethylcellulose, excipients, glucocorticoids, hypersensitivity, lactose, macrogols, povidone.

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Article Details

VOLUME: 15
ISSUE: 2
Year: 2016
Page: [91 - 100]
Pages: 10
DOI: 10.2174/1871523016666161109144021
Price: $58

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