Background: Nanostructured hybrid antibiotics (NHAs) are a new class of substances with a high
potential in the development of novel alternatives for antimicrobial treatments. This strategy is based on the
building of synergy between biologically-active organic and inorganic substances.
Objective: The aim of this study was to develop hydrogels based in cassava starch for controlled release systems
with antibacterial and antibiofilm properties using nanostructured hybrid systems.
Method: For that, hydrogels were synthesized from cassava starch and poly(acrylic acid) (PAA) by esterification
reaction. Silver nanoparticles were synthesized by chemical reduction using NaBH4 as reducing agent and
citrate as capping agent. Nanostructured hybrid systems were prepared from silver nanoparticles (AgNPs) and
cysteamine (cysa) by ligand exchange reaction; these systems were characterized (Fourier transform infrared,
dynamic light scattering, elemental analysis) and evaluated against Escherichia coli and Staphylococcus aureus
using Tryptic Soy Broth as liquid phase.
Conclusion: Hydrogels can be used as controlled-release systems of substance with antibacterial activity
(AgNPs, cysa and AgNPs-cysa). Antibacterial effect against Escherichia coli and Staphylococcus aureus was
seen to be relatively low at studied concentrations; however, the charge of antimicrobial activity can be controlled
as a result of high water absorption capacity. Inhibition percent for hybrid systems (AgNPs-cysa) was
seen to be most effective against Escherichia coli and very similar to the observed effect for AgNPs.